The GMO Panel assessed the herbicide tolerant maize, DP910521, which produces an insecticide and the selectable PMI marker gene (EFSA, 2024a). This event was developed to confer resistance to glufosinate and produce the Cry1B.34 toxin, which is a synthetic fusion of three different Cry-proteins originally derived from soil bacteria. The toxin is meant to be active against lepidoptera, such as fall armyworm (Spodoptera frugiperda), without it being clearly restricted to specific target species. The genetic intervention involved a multistep process using CRISPR/Cas to introduce a ‘landing pad’ at the target site, where the gene constructs for the production of new proteins (new traits) are subsequently inserted.